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Dozens of people in the capital city of Delhi are dead after a stampede broke out during evening prayers at a mosque in the city Tuesday. Thousands of men had gathered at an open-air mosque in west Delhi to pray when the stampede occurred, the Times of India reports. Officials say 100 people were killed and about 500 injured.

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Minimize TChem program

I’m writing a simple program for finding an optimal binding site for the protein ligand on a particular protein. I’m trying to minimize the force of the protein/ligand interaction using TChem to do the job.
I have the geometries of the protein and ligand in.pdb format. The ligand can take multiple conformations in solution as it can be flexible. In particular I’m trying to evaluate if there is a binding site between the surfaces of the ligand and the protein, so the ligand would be in either low or no mobility, this is why I’m forcing the ligand to only have one conformation.
Can anyone suggest the best way to do this? In particular what is the best system for defining the structure of the protein/ligand complex, because in fact TChem can

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